TNF-α Blockade-Associated ColitisĬD: Crohn’s disease JRA: Juvenile rheumatoid arthritis N/A: information not available RA: rheumatoid arthritis TB: tuberculosis TNF: tumor necrosis factor UC: ulcerative colitis.Ĭhronic active colitis with cryptitis, crypt abscesses, architectural distortion, dense lymphoplasmacytic infiltrateīloody diarrhea 2 weeks after his fourth infliximab inclusionĬessation of infliximab Parental steroids MesalamineĪrchitectural distortion, empty appearing lamina propria, cystically dilated crypts with atrophic epithelial lining, scattered apoptosis of basal crypt epitheliumĭiarrhea improved at 1 month following the last dose of infliximabģ died 9 recovered 1 without follow-up dataįeatures not well depicted in the text No pictures from H&E stained sections presented Pictures from immunostain equivocal for CMV at the mostĭeveloped abdominal discomfort, anorexia, epigastric pain, watery diarrhea at 10 days after the third dose of infliximabĬessation of infliximab and starting ganciclovir TNF-specific, PEGylated Fab’ antibody fragmentĪ fusion protein of two TNFR2 receptor extracellular domains and the Fc portion of human IgG perforation, bleeding, ischemia, necrosis, toxic megacolon)ĪS: ankylosing spondylitis CD: Crohn’s disease IBD: inflammatory bowel disease JIA: juvenile idiopathic arthritis PA: psoriatic arthritis PP: plaque psoriasis RA: rheumatoid arthritis TNF: tumor necrosis factor UC: ulcerative colitis. Grading Colitis-Associated With Medication/DrugĪsymptomatic, pathologic or radiographic findings onlyĪbdominal pain fever change in bowel habits with ileum peritoneal signs Biopsy from the terminal ileum from one patient treated with rituximab revealed mild surface intraepithelial lymphocytosis and a poorly formed non-caseating granuloma (a) ( H&E stain), and a lack of CD20+ lymphocytes (b) (immunoperoxidase stain).
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